{"product_id":"b00df3u7fc","title":"Bioisosteres in Medicinal Chemistry (Methods \u0026 Principles in Medicinal Chemistry)","description":"\u003cp\u003eWritten with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism.\u003cbr\u003e\nAs such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development.\u003c\/p\u003e\n\n\u003cp\u003eThe first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered,\u003cbr\u003e\nwhile the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part\u003cbr\u003e\ncovers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of\u003cbr\u003e\nprotein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed.\u003c\/p\u003e\n\n\u003cp\u003eWith its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.\u003c\/p\u003e","brand":"ANT","offers":[{"title":"Ebook","offer_id":52834953560280,"sku":"YSL57257","price":88.8,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0835\/3356\/2072\/files\/51WjVQn1IOL._SY1500.jpg?v=1793261870","url":"https:\/\/www.bookmebay.com\/products\/b00df3u7fc","provider":"BookMebay","version":"1.0","type":"link"}